2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-14664AS
    Fluvastatin-d6 sodium 98.98%
    Fluvastatin-d6 (sodium) is deuterium labeled Fluvastatin sodium. Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.
    Fluvastatin-d6 sodium
  • HY-159698A
    IONIS-DGAT 2Rx sodium
    IONIS-DGAT 2Rx (ION-224) sodium is a DGAT2 inhibitor, which is promising for research of atherosclerosis.
    IONIS-DGAT 2Rx sodium
  • HY-17376S1
    Ezetimibe-d4-1 1093659-89-2 99.26%
    Ezetimibe-d4-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
    Ezetimibe-d4-1
  • HY-17471AR
    Metformin hydrochloride (Standard) 1115-70-4 99.97%
    Metformin hydrochloride (Standard) is the analytical standard of Metformin (hydrochloride). This product is intended for research and analytical applications. Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.
    Metformin hydrochloride (Standard)
  • HY-B0006S1
    Carvedilol-d4 1133705-56-2 99.87%
    Carvedilol-d4 is the deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome.
    Carvedilol-d4
  • HY-B0309S2
    Felodipine-d3 1219795-30-8 98.10%
    Felodipine-d3 is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.
    Felodipine-d3
  • HY-W001940
    DL-m-Tyrosine 775-06-4 99.96%
    DL-m-Tyrosine shows effects on Arabidopsis root growth. Carbidopa combination with DL-m-tyrosine shows a potent hypotensive effect.
    DL-m-Tyrosine
  • HY-W002450
    L-Cyclohexylalanine 27527-05-5 ≥98.0%
    L-Cyclohexylalanine is an amino acid derivative. L-Cyclohexylalanine modifies an atrial natriuretic peptide, regulates homeostasis of body fluid and blood pressure homeostasis and vasodilation activity.
    L-Cyclohexylalanine
  • HY-W011082
    NLRP3-IN-2 16673-34-0 ≥98.0%
    NLRP3-IN-2, an intermediate substrate in the synthesis of glyburide, inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size following myocardial ischemia/reperfusion in the mouse, without affecting glucose metabolism.
    NLRP3-IN-2
  • HY-W015600
    2-Acetamidophenol 614-80-2
    2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation.
    2-Acetamidophenol
  • HY-W016644
    (S)-1-Benzylpyrrolidin-3-ol 101385-90-4 99.90%
    (S)-1-Benzylpyrrolidin-3-ol (Compound 14) can be used to synthesis impurities of the anti-hypertensive agent Barnidipine hydrochloride (HY-107322).
    (S)-1-Benzylpyrrolidin-3-ol
  • HY-W024271
    8-Hydroxyjulolidine-9-carboxaldehyde 63149-33-7 99.93%
    8-Hydroxyjulolidine-9-carboxaldehyde (9-Formyl-8-hydroxyjulolidine) is a highly selective fluorescent probe for hydrogen sulfide (S2−) and silicate (SiO32−). 8-Hydroxyjulolidine-9-carboxaldehyde operates via a mechanism of blocking intramolecular charge transfer (ICT), exhibiting significant fluorescence enhancement in the presence of weak acid ions. 8-Hydroxyjulolidine-9-carboxaldehyde is promising for research of fluorescence imaging of hydrogen sulfide within living cells.
    8-Hydroxyjulolidine-9-carboxaldehyde
  • HY-W088191
    4-Hydroxybenzamide 619-57-8 99.71%
    4-Hydroxybenzamide, found in the herb of Berberis pruinosa, is a known natural product that has potential to slow down the progression of atherosclerosis.
    4-Hydroxybenzamide
  • HY-W007606R
    Tyramine (Standard) 51-67-2
    Tyramine (Standard) is the analytical standard of Tyramine. This product is intended for research and analytical applications. Tyramine is an amino acid that helps regulate blood pressure. Tyramine occurs naturally in the body, and it's found in certain foods.
    Tyramine (Standard)
  • HY-12778
    Ivabradine metabolite N-Demethyl Ivabradine hydrochloride 1246638-08-3 99.63%
    N-Demethyl Ivabradine Hcl is a metabolite of Ivabradine, which is a specific inhibitor of the funny channel.
    Ivabradine metabolite N-Demethyl Ivabradine hydrochloride
  • HY-15195
    Avosentan 290815-26-8 98.15%
    Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.
    Avosentan
  • HY-15949
    Kif15-IN-2 672926-33-9 98.64%
    Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases.
    Kif15-IN-2
  • HY-19663
    Lemildipine 94739-29-4 99.58%
    Lemildipine is a new dihydropyridine calcium entry blocker.
    Lemildipine
  • HY-B0930
    Efloxate 119-41-5 99.73%
    Efloxate (Angorlisin) is a vasodilator used in the research of chronic coronary insufficiency and angina pectoris. Efloxate binds to Staphylococcus aureus sortase A.
    Efloxate
  • HY-B1061
    Nicotinic acid N-oxide 2398-81-4 99.92%
    Nicotinic acid N-oxide can be used for research on hyperlipidemia.
    Nicotinic acid N-oxide
Cat. No. Product Name / Synonyms Application Reactivity